Evidence

Plain-language summaries of the tirzepatide and semaglutide phase 3 trials and the head-to-head evidence, with sources and evidence grades.

• Semaglutide clinical trials: STEP and SELECT results in plain language

  What the phase 3 trials of semaglutide 2.4 mg found: weight change, comparators, the withdrawal trial, the cardiovascular outcomes trial, and what the results do not cover.

  Semaglutide · clinical review required

• Tirzepatide clinical trials: SURMOUNT and SURPASS results in plain language

  What the phase 3 trials of tirzepatide found: weight change by dose, comparators, durations, discontinuation, and what the results do and do not say about compounded copies.

  Tirzepatide · clinical review required

• Tirzepatide vs semaglutide: the head-to-head evidence

  What the direct comparison trial and the indirect comparisons show about weight change, tolerability, and where the two medications differ in cost and availability through telehealth.

  Tirzepatide · clinical review required